Wellbutrin
(Bupropion)
Wellbutrin is a unique antidepressant that works differently from SSRIs — its active ingredient, bupropion, increases dopamine and norepinephrine rather than serotonin. It is popular because it typically does not cause sexual side effects or weight gain and can improve energy and focus.
Most clients pay around $20 per session with insurance.
Wellbutrin is often chosen for people who have experienced unwanted sexual side effects or weight gain with SSRIs, or for those whose depression features low energy and poor concentration. Bupropion is also FDA-approved to help people quit smoking under the brand name Zyban.
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MD, Psychiatrist
Dr. Nathani works with clients on medication management that considers both clinical need and personal values, including conversations around fasting, stigma, and family concerns about psychiatric care.
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MD Psychiatrist
Dr. Butera provides thoughtful psychiatric evaluations and medication management, taking each client's full life, including their faith and values, into account when building a treatment plan.
Real questions. Honest answers.
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Wellbutrin (bupropion) works on dopamine and norepinephrine rather than serotonin. This means it tends not to cause the sexual side effects or weight gain common with SSRIs — and it can boost energy and focus.
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It is approved for major depression, seasonal affective disorder, and smoking cessation. It is also commonly used off-label for ADHD.
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Generally no — Wellbutrin is one of the few antidepressants associated with mild weight loss rather than gain in some people.
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Common side effects include dry mouth, headache, insomnia, and increased heart rate. At higher doses, there is a small increased risk of seizures.
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Yes — Wellbutrin is sometimes combined with an SSRI to address residual symptoms or offset sexual side effects. Your psychiatrist will manage the combination carefully.
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Wellbutrin is generally not the first choice for anxiety — it can occasionally increase it. It works better for depression with low energy than for anxiety-driven depression.
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Some people notice improved energy within the first couple of weeks. Full antidepressant effects typically come by week 4–6.
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Book a free consult at Outspace. Our psychiatrists will assess whether Wellbutrin is the right fit for your specific symptoms and history.