Depakote (Valproate)
Depakote is a mood stabiliser effective for both the manic and depressive phases of bipolar disorder. It has a long history of use in neurology and psychiatry and is also prescribed for epilepsy and migraine prevention.
Most clients pay around $20 per session with insurance.
Depakote works by increasing levels of GABA — a calming neurotransmitter — in the brain. Its active ingredient, valproate, is particularly strong for treating acute mania and preventing future episodes, though it carries important risks, especially for people who may become pregnant.
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Komal Nathani
MD, Psychiatrist
Dr. Nathani works with clients on medication management that considers both clinical need and personal values, including conversations around fasting, stigma, and family concerns about psychiatric care.
Adam Butera
MD Psychiatrist
Dr. Butera provides thoughtful psychiatric evaluations and medication management, taking each client's full life, including their faith and values, into account when building a treatment plan.
Real questions. Honest answers.
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Depakote (valproate) is FDA-approved for bipolar disorder (manic episodes), epilepsy, and migraine prevention. It is also commonly used off-label for other seizure disorders.
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Depakote carries a significant risk of birth defects and developmental problems in babies exposed in utero. It should not be used by people who may become pregnant without a thorough risk discussion with their doctor.
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Weight gain, tremor, hair loss, nausea, and fatigue are the most common. Liver function and platelet counts should be monitored regularly
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Depakote is metabolised by the liver and can, rarely, cause liver damage. Routine liver function tests are part of safe monitoring.
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Yes — weight gain is one of the most common concerns with Depakote. Diet and activity adjustments may help, and your psychiatrist can discuss alternatives if this becomes a significant problem.
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Depakote works relatively quickly — significant improvement in acute mania is often seen within 1–2 weeks, which makes it useful in acute settings.
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No — alcohol significantly increases the risk of liver damage and can worsen side effects. Avoid alcohol while on Depakote.
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Book a free consult at Outspace. Our psychiatrists will assess whether Depakote is appropriate and discuss all risks and monitoring requirements with you.